An Introduction To Serrapeptase – The Miracle Enzyme

1. An Introduction to the Miracle Enzyme

Serrapeptase is a protein enzyme that accelerates biochemical reactions in the body. It is also known as Serratiopeptidase and is produced by the enterobacterium Serratia E-151.

Enzymes Basics

Enzymes and enzyme pathways are an integral part of the human body.

For example malfunctioning enzyme pathways due to diseases including cancer can often be intervened in, as a result switching off the disease.

Researchers often discover how these pathways are activated and then either work to activate or block these enzyme pathways.

Enzymes perform a range of tasks which supports cells in the human body.

When an enzyme malfunctions due to genetic and or external circumstances this lead to the onset of diseases.

Serrapeptase’s History

Serrapeptase is derived from the intestines of the silkworm. Silk worms primarily produce Serrapeptase to break down their cocoon walls2.

Scientists studying the silkworms discovered Serrapeptase to be a proteolytic enzyme. Proteolytic means to break down proteins.

One of the reasons why proteolytic enzymes are important is because they are able to decompose all types of proteins found in the human body which as a result can prevent illnesses.

Excess Protein Lumps

When excess protein lumps and particles accumulate in organs, arteries or tissues obstructions and immune response is activated.

Hence these proteins need to be removed from the body.

What Type Of Proteins Are We Talking About?

We are not talking about healthy tissues and muscles in the body that are made of protein.

What we are talking about essentially is all the dead proteins that are left behind as a result of the various biochemical and metabolic processes that happen in the body. These waste protein particles need to be eliminated by the body.

When protein is not effectively dissolved in the body, i.e. made small enough, the body has to work harder to first break it down and then eliminate it.


Due to illness, the body works slower than usual to keep up with protein decomposition as the diseases keep producing an excess amount compared to a healthy person – as a result the body becomes overwhelmed.

Supporting Protein Decomposition

The body can benefit from supplementing with proteolytic enzymes- which help support the decomposition of protein substances and masses found in the body.

Safe to Healthy Tissue

Serrapeptase will not attack healthy protein tissues in the body. As the chemical structure does not allow Serrapeptase to be able to attach to it.

It will only work on leftover protein substances such as cysts and clots.

Prevent Thrombosis

Hence proteolytic enzymes such as Serrapeptase are extremely beneficial as they can help to prevent thrombosis – blood clots from forming.

This is due to the mechanism that Serrapeptase enzyme has on the circulatory system – by dissolving and reducing arterial plaque – fatty cholesterol, calcium and other foreign protein materials from sticking to arterial walls.

Taken as a supplement proteolytic enzymes can help to improve the cardiovascular system and greatly improve overall health.

Proteolytic Enzymes

Proteolytic means able to break down proteins. The body already has an inherent proteolytic system, which breaks down all proteins making them available to the body, which can then be used for repair and regeneration processes.

Serrapeptase is categorized as a Proteolytic enzyme3.Enzymes are categorised according to function they play within organisms including the human body.

Protease Enzymes

Protease enzymes are used to digest proteins. The proteins we consume through our diet, need to be broken down into individual amino acid and polypeptide molecules.


Proteolysis, which is the breakdown of proteins via water is a process that is undertaken in all organisms.

The human body accumulates a great deal of protein by-products, as a result of various biochemical processes that are taking place in the body.

Excess Fibrin

Due to faulty digestive processes, all the protein that should have been broken down via protease enzymes, does not get broken down. This leaves half digestive protein molecule chains, which can then be absorbed into the bloodstream. This triggers an immune reaction, such as an immune complex to be created by the body.

Also due to illnesses and various other disease processes that are being undertaken in the body, excess protein, aka fibrin is produced. This protein now needs to be cleared out, otherwise it accumulates in the body.

When there is excess protein that is circulating throughout the arteries, it can create protein clots within the blood. Which can then lead to arterial blockage leading to heart attack or stroke.

2709 Enzymes – Identified in the Human Body

Researchers were able to identify 2,709 different types of enzymes in the human body4,which are catalysts in 896 bio reactions.

Metabolic Processes

All the tissues in the body need to be built via protein consumed from food.

When the body needs to produce energy some of this protein is broken down. Metabolic enzymes play a role in this.

Metabolic Enzyme roles5 include:

622 enzymes are important in 135 metabolic pathways.

Protease enzymes are found in the small intestines, they can also be taken in supplemental form to improve health.

Enzymes in the Blood Stream

Enzymes can travel in the blood stream seeking out:

  • Fibrin – extra protein not used by the body
  • Blood Clots – due to injury or repair processes
  • Benign Cysts – masses that form from scar tissue or growths
  • Dead Tissue – tissue that has died and not been eliminated by the body
  • Arterial Plaque – found in the vascular system

When enzymes encounter protein substances such as above which are a waste product, which the body does not use, it can safely dissolve and help the body to eliminate it.

Preventing Clots

Enzymes can begin to dissolve the protein, as a result – preventing the likelihood of clots and cysts forming within arteries, which can obstruct arteries leading to heart attack.

Individuals suffering from heart disease including arterial plaque related disorders such as Atherosclerosis6 have protein, fat and calcium build up in their arteries. This narrows the arteries.

As such Serrapeptase enzyme may benefit by helping removing these protein deposits – fibrin – proteins used in repairing tissues and other organs. As well as dissolving clots that accumulate in the human body.

Dissolving Fibrin – Left Behind

Fibrin3 is a category of proteins in our body. The body is naturally adept at repairing damage from physical trauma, surgery and injuries – replacing the old with new cells, tissues, muscles.

Dead Tissues

However, what happens to all the previous injured protein cells and tissues?

This tissue was once living protein, and as it now injured or dead, it needs to be broken down now, and replaced with new protein cells and tissues.

So the body inherently has system to be able to break this down and replace it with new proteins.

Once the body has healed, i.e. all the replacements have taken place, the excess protein left from the injury known as fibrin needs to be eliminated by the body.

Elimination is slow as without repair functions taking priority the body can die.

Regeneration and Repair

The body’s priorities are regeneration and repair. Then the elimination of the old waste material.

However, when you have an illness.

This system can become backed up due to slow elimination. When this protein waste is not eliminated. It can create serious problems in the body, such as new benign masses, as well as attaching to pathogenic bacteria and masses in the body, which can flow through the circulatory system, creating clots and obstructions which can lead to fatal diseases.

Components in Protein Clots

  • Fibrinolysis – a process that separates fibrin and breaks down clots
  • Fibrinolytic – includes primary fibrinolysis – due to normal body process Secondary fibrinolysis – is the breakdown of clots due to medications and diseases
  • Proteolysis – is the breakdown of proteins into smaller polypeptides or amino acids, also known as proteolytic
  • Thrombolysis: Process that breaks down clots. Thrombolytic therapy, is a treatment to dissolve dangerous clots in blood vessels, improve blood flow, and prevent damage to tissues and organs due to lack of circulation

2. Serrapeptase and Chronic Inflammation

All diseases produce a certain amount of inflammation which is correlated to how serious the disease is.

Hence inflammation may be minimal or excessive. Serrapeptase as an anti-inflammatory has shown to be able to reduce Inflammation in the Body

Activating White Blood Cells

Inflamation triggers the immune system into releasing and activating white blood cells. White blood cells travel through the circulatory system – seeking out to destroy pathogenic bacteria, foreign substances and cancer cells.

Chronic Inflamation

Long term low level chronic inflammation must not be ignored as it is a contributing factor in thousands of different types of diseases.

Chronic inflammation needs to be dealt with urgently.

The analogy can be likened to a forest fire it burns slowly and then gains momentum engulfing the whole forest.

Similarly in our body inflamation burns slowly until it grows out of hand. Many Diseases can be stopped and even reversed if healthy interventions are done at the right time.

Anti-inflammatory Agents

Serrapeptase has primarily shown to be an antiinflammatory agent. Hence inflammatory diseases may benefit from Serrapeptase.

Serrapeptase enzymatic and anti- inflammatory effects on a number of conditions include:

  • Dissolving Dead Tissue– such as arterial plaque, blood clots and cyst as well as inflammatory related disorders
  • Mucous Thinner – reducing excess fluid so that the body can drain it naturally
  • Reduces Inflamation – inflammation that is caused due to wear and tear in the body

Serrapeptase helps reduce chronic inflammation as it is an anti-inflammatory.

Autoimmune Diseases


As well as promoting an antibacterial effect due to infections as a result of surgery.

Inflamed Tissues & White Blood Cells

Tissue Inflamation triggers excessive white blood cells to be released into the bloodstream. White blood cells can leak into organs and tissues as they undertake their repair tasks.

The sudden high activity of these white blood cells can cause tissue damage.

Autoimmune Diseases

Autoimmune diseases are as a result of the body’s own cells attacking itself. Hence during surgery when the immune system is highly alert, it releases a lot of white blood cells damaging nearby tissue.

Serrapeptase is an anti-inflammatory, able to reduce tissue inflammation as well as prevent swelling after surgery.

3. Serrapeptase and Heart Disease

Dr Hans Nieper, a German physician used Serrapeptase to help coronary heart disease patients dissolve arterial plaque7. He was so surprised with Serrapeptase’s ability to remove arterial plaque and blockages that he preferred using Serrapeptase to EDTA chelation treatments that he was also researching at the time, to help prevent Coronary thrombosis – blood clots which can form in coronary artery lead to a heart attack.

Chelation Therapy

Chelation means to bind to therefore binding to chemicals in the body. Chelation therapy is where a chemical solution known as EDTA (ethylene diamine tetra acetic acid)—is injected into the bloodstream.

The solution targets and removes heavy metals, minerals, foreign particles and substances from the body. This used to be a way of clearing arteries of plaque.

Serrapeptase has been used as an alternative to chelation therapy. As it is a natural chelator that binds to arterial plaque and sweeps away excess fatty deposits in the arteries.

Serrapeptase Heart Disease Benefits:

  • Removes Dead Protein Tissue – waste fells such as dead cells, cysts and growths that can constrict coronary arteries
  • Reduces Plaque Build- Up – and promotes easier blood flow hence clearer arteries
  • Improves Circulation – to all major organs in the body especially the heart
  • Natural Alternative – compared to Non Sterol Anti-inflammatory Drugs (NSAID)
  • Minimal Side Effects – does not cause bleeding and stomach ulcers
  • Lung And Chest Congestions –       can be reduced
  • Immune System – Does not depress the immune system – as many medications do

With regular use the Serrapeptase enzyme may completely reverse arterial damage and prevent future plaque from building up.

As a preventative supplement it can protect the arteries naturally from oxidative damage caused by fibrin, fatty deposits and calcium.

Healing the Arteries Reduces the Long Term Risks Associated With Heart Disease and Cancer

Clearer arteries6 reduces the risks of suffering from heart attacks and strokes in the future.

Research with Serrapeptase demonstrated arteries to be completely clear of all arterial plaque blockages7. This led to the conclusion that Serrapeptase can safely dissolve and remove dead proteins in the body which can be eliminated naturally.

This may benefit as well as prevent and avoid intrusive medical measures such as.

  • Coronary Bypass Surgery – operation to improve the blood supply to the heart can be risky
  • Angioplasty – surgical treatment to expand a narrowed artery

Serrapeptase helps with a wide variety of health conditions.

It is beneficial for people over 40 to take Serrapeptase as a backup, in keeping the body safe from clots and cysts of all types.


Serrapeptase Blood Pressure Benefits

Due to it mechanism in the way that it is able to interact with arterial plaque and dissolve it – may help to reduce blood pressure.

Serrapeptase has:

  • Detoxifying Effect- on the blood – it clears up dead protein waste fatty cells, calcium deposits and blood clots
  • Thins the blood – Promotes healthy blood flow in arteries.

What is Arterial Plaque Made Up of?

Arterial plaque is made up of – protein substances cholesterol, calcium and fibrin including foreign substances such as – dead cells and bacteria.

When blood flows into these substances – blood coagulates and create a protein mass in the artery like a cyst. As it flows through the artery it sticks to other protein materials.

Proteins Coat Arterial Walls

Some of the protein material coats the artery walls. As a result, the arteries become smaller, while the arterial lining plaque becomes thicker.

There is now less space for the blood to be able to flow effectively through the arteries. This puts enormous pressure on the heart where a lack of oxygen can lead to a heart attack.

The heart will also struggle to pump enough blood to all parts of the body.

As Serrapeptase is a proteolytic, thrombolytic, as well as fibrinolytic enzyme – it will target arterial plaque, be able to help prevent the growth of thrombi and emboli which are clots in the arteries.

As well as help clear the fatty coating which is attached to arterial walls.

Optimum Blood Flow Lowers Blood Pressure

Hence allowing optimum blood flow to be able to take place.

Naturally, this will lower blood pressure. The heart does not have to work as hard to pump blood through the arteries.

Leading to lower arterial resistance – which is the pressure exerted on the arterial walls due to blood, which was unable to flow through the arteries.

Serrapeptase May help elderly and those with limited mobility who are affected by Orthostatic hypotension – drop in blood pressure brought when a person changes in body position, such as rising from a chair, bed, getting up from sitting down.

4. Fluid Retention and Serrapeptase – Oedema, Ascites and Lymphoedema

Serrapeptase may benefit individuals suffering from diabetes, congestive heart failure and kidney failure. All 3 conditions results in fluid retention – oedema as the disease progresses.

Oedema also creates Excess fluid and mucous in the body can create further problems such as bacterial infections.

Lung Health

Research suggests that Serrapeptase may be beneficial for lung health – conditions such as chronic bronchitis and emphysema.

Serrapeptase helps to clear mucus and lung secretions accumulated in the lungs by thinning the secretions out so that the body can drain it easier. This helps to prevent bacterial infections.

Bacterial Infections – Mucus and Biofilms

The human body creates mucous daily this helps it to trap bacteria and other foreign particulate matter and substances that invade the body, through air, food and bacterial organisms.

As well as play a role in supporting key organs such as the digestive tract in the body.

Mucus is created out of glycoproteins, a combination of sugar and proteins that creates a slippery white substance

However, excessive mucus can lead to problems such as dried mucous clots which can cause obstructions.

Bacterial Mucous – Biofilm

Bacteria create a type of mucus, known as a biofilm which they use to hide underneath. Bacterial colony units survive better within the microbiome environment when hidden under biofilms.

This biofilm grows and expands as the bacterial community grows.

Bacterial Diversity

The human body is a home to thousands of different types of bacteria. As such a huge bacterial diversity exists within the human body- where pathogenic bacteria exist amongst the good bacteria.

Harmful Bacterial Communities

Pathogenic bacteria can take over the environment by expanding and growing underneath biofilms – they also excrete toxins driving good bacteria away monopolising key locations.

When the immune system is weak or compromised – as a result creating infections which creates inflamation in the body.

Stealing the Body’s Nutrients

Bacteria also steal the body’s nutrients intended for healthy cells. Excreting waste products which are cytotoxic to healthy cells in the body. This places a huge burden on the lymphatic system.

Lymphatic System

The tasks undertaken by the lymphatic system are to carry all extracellular waste away from the cellular environment and filter this waste to be eliminated from the body.

Overburdened Lymphatic System

The lymphatic system can become overburdened with bacterial protein wastes. The lymph nodes have to filter this by first dissolving protein waste, bacteria, cancer cells, and foreign particulate matter. The lymph fluid then circulates to carry back new waste.

As Serrapeptase is a proteolytic enzyme. It may help to dissolve protein debris floating around in the extracellular environment. Dead bacterial cells as well as biofilms and cancer cells protein shells floating around.

As a result this supports the lymphatic system as there is less protein for the lymphatic system to be able to dissolve.

5. Serrapeptase Arthritis

The majority of inflammatory health conditions may benefit from Serrapeptase supplementation as it helps to reduces swelling and the stiffness of joints.

As a natural inflammatory it is effective at helping reduce pain.

As a result this supports the lymphatic system as there is less protein this for the lymphatic system to be able to dissolve.

  1. Serrapeptase Arthritis

The majority of inflammatory health conditions may benefit from Serrapeptase supplementation as it helps to reduces swelling and the stiffness of joints.

6. Serrapeptase and Fibroids

Serrapeptase may be able to shrink cysts and fibroids as well as support cystic breast disease. It is a natural remedy for helping shrink uterine fibroids and reducing swelling.

Serrapeptase and Endometriosis

The cells of endometriosis often implant themselves outside the uterus, and can be found in the fallopian tubes as well as other areas of the uterus or intestines. Creating inflamation, infection and obstructions in the body.

Women suffering from endometriosis may benefit from using Serrapeptase. Although fibroids are mostly benign they can cause obstructions to arteries, veins and capillaries affecting the blood flow. Serrapeptase is a blood thinner that can help promote blood flow while helping to dissolve protein clots and cysts safely.

7. Serrapeptase for Cancer

Serrapeptase may be able to support cancer – related symptoms indirectly.

By supporting the immune system which in turn kills the cancer cells.

Serrapeptase also thins out the extracellular fluid, so there is less likelihood of protein lumps from forming. Reducing the likelihood of metastasis.

Cancer Inflamation

Cancer creates a highly inflammatory state in the body. When cancer cells metastasise they damage and destroy nearby tissues by injecting cytotoxins into tissues.

When tissues are damaged, they trigger an inflammatory marker (TPA) which is detected by the immune system.

Toxic Cellular Environment

This creates a highly toxic cellular environment as

Cancer cells excrete cytotoxins, leading to the death of healthy cells.

The immune system, then activates white blood cells – the natural killer cells as well as cytotoxic t cells to travel to the local area to help repair the damage caused by cancer cells.


Cancerous tumours initiate the process of angiogenesis – which is the creation of their own blood supply network. This network makes the cancer self-sufficient – which brings blood with nutrients such as sugar to feed and help promote tumour growth.

Diverting the body’s resources via cachexia, so as to be able to bring glucose to help support their growth.

Cancer and Blood Circulation

Tumours growth is increased exponentially in areas of low oxygen – known as hypoxia.

We can see why good circulation is extremely critical when an individual is suffering from cancer.

Without optimal oxygen being transported into damaged tissues in the body, cancer will continue to metastasise.

As Serrapeptase can help to clear up the arterial plaque in the cardio vascular system.

It may indirectly help promote oxygenation of body tissues. As a result, the vascular system can deliver essential oxygen, nutrients and substances required by the cells in the body so that they are able to fight the effects of cancer effectively.

8. Side Effects of Using Serrapeptase

Long term studies have not shown any major side effects, however as with any new supplementation routine always consult with your doctor and always start off with a small dose.

Contra indications:

If you are taking any medications for any illness always read the prescription leaflet of the medications you are taking carefully.

Ensure that you are not double dosing i.e. taking twice the amount of a type of medicine or herb

  • Blood Thinning Medications – such as Statins or NSAID’s
  • Anticoagulants – medicines that decreases blood’s ability to clot
  • Antiplatelet Agent medication to stop blood clots from forming such as aspirin
  • Warfarin – also an anticoagulant
  • Heparin – related procedures where – a natural polymer used as an injectable anticoagulant in surgical procedures
  • Heparinoids – similar having anti-clotting agent’s activity resembling that of a heparin.

Serrapeptase is a safe and gently enzyme complex that is gaining popularity in the natural health word as a potent natural remedy for many diseases.

9. Summary of Serrapeptase

Serrapeptase enzymes are a great health supplement that can help support a range of health conditions.

Serrapeptase is:

  • Proteolytic Enzyme – breaks down proteins
  • Fibrinolytic Enzyme – prevents excess clots being formed in the body
  • Thrombolytic Enzyme – prevents excess blood clots
  • Anti-inflammatory – reduces the effects of inflamation
  • Antimicrobial – reduces biofilm – hence reduction in bacterial infections
  • Supports The Immune System – in a range of diseases
  • Cardiovascular System – prevents heart disease

What Conditions Does Serrapeptase Treat?

Health conditions Serrapeptase may help support

  • Arthritis
  • Rheumatoid Arthritis
  • Sinusitis
  • Cardiovascular – heart disease

Lung Problems

  • Cough
  • Bronchitis
  • Bronchial asthma
  • Chest problems
  • Emphysema
  • Diabetes
  • Prostate problems
  • Osteoporosis
  • Breast engorgement
  • Fibrocystic breasts
  • Fibromyalgia
  • Multiple sclerosis

As well as a range of inflammatory diseases.

If you would like to purchase Serrapeptase. You can buy from the good health store a trusted seller of Serrapeptase for many years.

Click here to go to the good health store.

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Further Reading:

  1. Nirale NM, Menon MD. Topical formulations of serratiopeptidase: development and pharmacodynamic evaluation. Indian J Pharm Sci. 2010;72(1):65-71. doi:10.4103/0250-474X.62246.
  2. Redfern R. Miracle Enzyme Is Serrapeptase: The 2nd Gift from Silkworms. Naturally Healthy Publications; 2009.
  3. Jickling GC, Zhan X, Ander BP, et al. Genome response to tissue plasminogen activator in experimental ischemic stroke. BMC Genomics. 2010;11(1):254. doi:10.1186/1471-2164-11-254.
  4. Romero P, Wagg J, Green ML, Kaiser D, Krummenacker M, Karp PD. Computational prediction of human metabolic pathways from the complete human genome. Genome Biol. 2005;6(1):R2. doi:10.1186/gb-2004-6-1-r2.
  5. Goldman AD, Baross JA, Samudrala R. The enzymatic and metabolic capabilities of early life. PLoS One. 2012;7(9):e39912. doi:10.1371/journal.pone.0039912.
  6. Atherosclerosis. NHS.
  7. NIEPER HA. The Curious Man: The Life and Works Of Dr. Hans Nieper. AuthorHouse; 2010.